diff --git a/codex-rs/cli/src/main.rs b/codex-rs/cli/src/main.rs
index 4382dee292..929d1b8654 100644
--- a/codex-rs/cli/src/main.rs
+++ b/codex-rs/cli/src/main.rs
@@ -918,7 +918,9 @@ async fn cli_main(arg0_paths: Arg0DispatchPaths) -> anyhow::Result<()> {
             )?;
             // Propagate any root-level config overrides (e.g. `-c key=value`).
             prepend_config_flags(&mut mcp_cli.config_overrides, root_config_overrides.clone());
-            mcp_cli.run().await?;
+            let loader_overrides =
+                loader_overrides_for_profile(interactive.config_profile_v2.as_ref())?;
+            mcp_cli.run(loader_overrides).await?;
         }
         Some(Subcommand::Plugin(plugin_cli)) => {
             reject_remote_mode_for_subcommand(
@@ -1459,11 +1461,12 @@ fn profile_v2_for_subcommand<'a>(
         | Subcommand::Review(_)
         | Subcommand::Resume(_)
         | Subcommand::Fork(_)
+        | Subcommand::Mcp(_)
         | Subcommand::Debug(DebugCommand {
             subcommand: DebugSubcommand::PromptInput(_),
         }) => Ok(Some(profile_v2)),
         _ => anyhow::bail!(
-            "--profile only applies to runtime commands: `codex`, `codex exec`, `codex review`, `codex resume`, `codex fork`, and `codex debug prompt-input`."
+            "--profile only applies to runtime commands and `codex mcp`: `codex`, `codex exec`, `codex review`, `codex resume`, `codex fork`, `codex mcp`, and `codex debug prompt-input`."
         ),
     }
 }
@@ -2264,6 +2267,12 @@ mod tests {
                 .as_deref(),
             Some("work")
         );
+        assert_eq!(
+            profile_v2_for_args(&["codex", "--profile", "work", "mcp", "list"])
+                .expect("mcp supports profile-v2")
+                .as_deref(),
+            Some("work")
+        );
     }
 
     #[test]
diff --git a/codex-rs/cli/src/mcp_cmd.rs b/codex-rs/cli/src/mcp_cmd.rs
index f52d24160b..3104262c23 100644
--- a/codex-rs/cli/src/mcp_cmd.rs
+++ b/codex-rs/cli/src/mcp_cmd.rs
@@ -11,6 +11,8 @@ use codex_config::types::McpServerConfig;
 use codex_config::types::McpServerTransportConfig;
 use codex_core::McpManager;
 use codex_core::config::Config;
+use codex_core::config::ConfigBuilder;
+use codex_core::config::LoaderOverrides;
 use codex_core::config::edit::ConfigEditsBuilder;
 use codex_core::config::find_codex_home;
 use codex_core::config::load_global_mcp_servers;
@@ -157,12 +159,16 @@ pub struct LogoutArgs {
 }
 
 impl McpCli {
-    pub async fn run(self) -> Result<()> {
+    pub async fn run(self, loader_overrides: LoaderOverrides) -> Result<()> {
         let McpCli {
             config_overrides,
             subcommand,
         } = self;
 
+        if loader_overrides.user_config_profile.is_some() {
+            validate_profile_v2_migration(&config_overrides, loader_overrides).await?;
+        }
+
         match subcommand {
             McpSubcommand::List(args) => {
                 run_list(&config_overrides, args).await?;
@@ -239,6 +245,22 @@ async fn perform_oauth_login_retry_without_scopes(
     }
 }
 
+async fn validate_profile_v2_migration(
+    config_overrides: &CliConfigOverrides,
+    loader_overrides: LoaderOverrides,
+) -> Result<()> {
+    let overrides = config_overrides
+        .parse_overrides()
+        .map_err(anyhow::Error::msg)?;
+    ConfigBuilder::default()
+        .cli_overrides(overrides)
+        .loader_overrides(loader_overrides)
+        .build()
+        .await
+        .context("failed to load configuration")?;
+    Ok(())
+}
+
 async fn run_add(config_overrides: &CliConfigOverrides, add_args: AddArgs) -> Result<()> {
     // Validate any provided overrides even though they are not currently applied.
     let overrides = config_overrides
diff --git a/codex-rs/cli/tests/mcp_add_remove.rs b/codex-rs/cli/tests/mcp_add_remove.rs
index 15afaf0828..ecfbed1264 100644
--- a/codex-rs/cli/tests/mcp_add_remove.rs
+++ b/codex-rs/cli/tests/mcp_add_remove.rs
@@ -68,6 +68,28 @@ async fn add_and_remove_server_updates_global_config() -> Result<()> {
     Ok(())
 }
 
+#[tokio::test]
+async fn profile_mcp_reports_legacy_profile_migration() -> Result<()> {
+    let codex_home = TempDir::new()?;
+    std::fs::write(
+        codex_home.path().join("config.toml"),
+        r#"[profiles.work]
+model = "gpt-5"
+"#,
+    )?;
+
+    let mut list_cmd = codex_command(codex_home.path())?;
+    list_cmd
+        .args(["--profile", "work", "mcp", "list"])
+        .assert()
+        .failure()
+        .stderr(contains("--profile `work` cannot be used"))
+        .stderr(contains("[profiles.work]"))
+        .stderr(contains("work.config.toml"));
+
+    Ok(())
+}
+
 #[tokio::test]
 async fn add_with_env_preserves_key_order_and_values() -> Result<()> {
     let codex_home = TempDir::new()?;